No expert here on PC or gearing, but have dabbled with both on a 749S.
THe PC3 was fitted because the ECU that came with the Termi blew and as Ducati were out of stock was likely to leave me with no bike for the remainder of the season. Fitted the standard ECU and a PC3, with a curstom map done on the Dyno. Total price £350 for the PC3, fitted, and Dyno.
I have seen the graphs from before and after. The before was incorrect fuelling because the ECU was for std exhaust and the Termi/filters made it run very lean with that. Also, there is a dip in the curve at mid revs and that has been smoothed out a bit.
Hoever .... The main difference to me after getting the bike back is the throttle response. It seems to be very responsive now, but it's marginal. I like it anyway.
Gearing ... I have played with gearing on both 749S and an ST4S (accidentally). I wanted a bit more go for the 749S so I increased the rear srpocket 2 teeth. This (roughly) equates to half a tooth on the front, and makes it accelerate quicker at the expense of top speed. The effect is to put you up in the 4-5k revs area rather than the 3-4k region, so it's more ready to go when you open the throttle. I think I like it, but it'd be interesting to try the bike back on standard gearing again for comparison now. The 749S already has the 14T front sprocket, and you should not go any lower that on the front as the chain will be unhappy!
On the ST4S I ordered what I thought (as per manual) was the correct sprocket sizes and found the rear was 4 teeth bigger than the one I had (equates to 1 down on front). It certainly woke it up, and it was a bit too easy to get the front wheel in the air when pulling out in to traffic. Of course, I liked to ride it hard after that changes because it felt so quick, and it wore the sprcket very quickly (anodised aluminium sprocket).
Hope some of that helps.