Istan
A few tips, take a tank bag, good for resting your chest on, good earplugs cut the wind noise and take nsaids - non steroidal anti-inflamatories (Paracetomol or ibruprofen). Seriously I tend to get aches in the shoulders after a few hours, take a dose of both and it really stops the uncomfortableness.
I have a 14T front sproket to lower the gearing and I found it was perfect for A and B road blasting. I managed about 145 miles until the red light which was about the right time to get off and stretch.
Finally, a good tip that I didn't follow is to fit a sport touring rear tire, a Bridgestone BT020 rather than a BT 010 or 012, this will reduce the squaring of the tire becuase it is dual compound with a harder compound in the middle.
Rob
PS fit some loud pipes (I have Akrapovic) to entertain the villages as you pass through - I'm thoughtful like that