I don't commute either, and I agree with DCR, it does get at your wrists when riding in town. The seat hasn't been a problem for me (guess its all the excess padding on the glutes!!).
Motorways are no trouble, and I found it a little comfier than 748s and 996s I tried before I bought the 749.
I've just had Termi asymmetric system fitted to mine (although its yet to be set up), and the sound is fantastic, really addictive!
I think you should go for it, theres plenty of knowledgable people here...you won't regret it at all.
