Wrists could be a bike fitness thing, give it a while and you might get used to it. I struggled at first on my old 748 and adapted my hand position slightly over time and found I had no problems and even ended up doing a 700 miles blast from Dijon to Yorkshire only stopping for fuel and coffee and I had no wrist problems at all.
Tyres...bane of my life at the moment, ever since I upgraded to the 748R I have not got on at all well with the Dragons that are fitted. Must change them soon
