If you've been riding since you were 4 and done over 250k miles then you need new hands. The recommended replacement period is 50 years or 200k miles, whichever comes first.
Dukes are a lot more vibey than any other bikes I've had. Do you have access to another one to compare whether yours is better/worse than normal?
If your is the same or less vibey then bar-end weights should help or liquid snake (
www.barsnake.com).
If yours is more vibey than normal then call Nelly at Cornerspeed!